- Adrien Brody as Clive Nicoli
- Sarah Polley as Elsa Kast
- Delphine Chanéac as Dren
- Brandon McGibbon as Gavin Nicoli
- Simona Maicanescu as Joan Chorot
- David Hewlett as William Barlow
- Abigail Chu as Child Dren
Clive (Adrien Brody) and Elsa (Sarah Polley) don’t want much out of life except to save the world from genetic diseases. To do that, they’ve begun splicing the genomes of various animals together in order to create living laboratories for new vaccines. But when the heartless corporation they work for decides they’re going to have to give up the sexy lab work and spend a few years on actually making money, well that’s just too far. Instead they decide to go the next step forward secretly, mixing human genes into their program by themselves and without telling anyone. What could go wrong?
When you start out with your main characters named after the lead actors from “Bride of Frankenstein” you can be pretty sure you’re in for a big homage and that’s more or less what we get from “Splice.” Same prescriptive about the dangers of meddling with nature, same obvious lack of concern about the psychological care for the creation. It’s been what, 150 some odd years since Mary Shelly wrote the original template and no one has been able to really build on that since James Whale’s seminal film. If it ain’t broke, don’t fix it, I guess.
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